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山东保鲜库养殖食用菌喜获成功 低温天气下食用菌栽培防范措施
洛巴口蘑滤液中多糖蛋白复合物的抗肿瘤机制 ANTITUMOR MECHANISM OF POLYSACCHARIDE-PROTEIN COMPLEX FROM THE CULTURE FILTRATE OF TRICHOLOMA LOBAYENSE 刘方 黄容春 邢来君 赵力 张树庭 摘要:从洛巴口蘑培养滤液中分离出一种具有抗肿瘤性的多糖蛋白复合物(PSPC).PSPC在细胞水平有能力恢复和增强带瘤鼠腹腔浸出细胞的吞噬功能和T细胞的促活性.在分子水平,PSPC能恢复带瘤鼠脾细胞和腹腔浸出细胞内IFN-γ基因的表达水平.另外,PSPC能够下调带瘤鼠脾细胞内抗细胞因子”TGF-β的表达水平.因此,PSPC的抗肿瘤机制可归咎于寄主介导的免疫调节作用. 关键词:多糖,蘑菇,细胞因子,免疫调节 分类号:Q939.93 文献标识码:A 文章编号:1007-3515-62000)03-0396-0400 作者单位:刘方(天津南开大学微生物系 天津 300071) 黄容春(香港中文大学生物系 香港) 邢来君(天津南开大学微生物系 天津 300071) 赵力(天津医院 天津 300211) 张树庭(香港中文大学生物系 香港) 参考文献: [1]Abbas A K,Lichtman A H,Pober J S,1991.Cellular and Molecular Immunology.Philadelphia:W.B.Sannders [2]Berg D J,Lynch R G,1991.Immune dysfunction in mice with plasmacytomas,I.Evidence that transforming growth factor-βcontributes to the altered expression of activation receptors on host B lymphocytes.The Journal of Immunology,146:2865~2872. [3]Callard R E,1990.Cytokines and B Lymphocytes.London:Academic Press [4]Chang R,1996.Functional properties of edible mushroom.Nutrition Reviews,54:91~93. [5]Chang S T,Mao.X L,1995. Hong Kong Mushrooms.Hong Kong:The Chinese University of Hong Kong Press,79~80. [6]Kehrl J H, Roberts A B,Wakefield L M,et al.,1986.Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.The Journal of Immunology,137:3855~3860. [7]Leung M Y,Fung P K,Choy Y M,1997.The isolation and characterization of an immunomodulatory and antitumor polysaccharide preparation from Flarmmulina velutipees.Immunopharmacology,35:255~263. [8]Liu F,Ooi V E C,Chang S T,1995.Antitumor components of the culture filtrates from Tricholoma sp.World Journal of Microbiology and Biotechnology,11:486~490. [9]Liu W K,Mak N K,Wong C C,1989.Immunomodulatory effect of methimazole on inbred mice.Immunobiology,18:23~32. [10]iu W K,Ng T B,Sze S F,et al.,1993.Activation of peritoneal macrophages by polysaccharopeptide from the mushroom,Coriolus versicolor.Immunopharmacology,26:139~146. [11]Mizuno T,Saito H,Nishitoba T,et al.,1995.Antitumor-active substances from mushrooms.Food Review International,11:23~61. [12]Shibata Y,Tamura K,Ishida N,1983.In vivo analysis of the suppressive effects of immunosuppressive acidic protein,a type of alfa-1 acid glycoprotein,in connection with its high level in tumor-bearing mice.Cancer Research,43:2889~2896.